Danish scientists: Espresso puts an end to diabetes

An ingredient in coffee helps end diabetes, but to do so you should drink espresso and avoid filter coffee, according to a Danish study. Diabetes mellitus  Consuming three to four cups of coffee. A day has been shown to reduce the risk of developing. Type 2 diabetes by 25% compared to those who drink one cup or less. Caffeine is believed to be responsible for this But this was later revised, and decaffeinated coffee had the same effect.

Diabetes: What role does coffee cafestol play?

Danish scientists have found that one of these previously tested chemicals in coffee, cafestol, appears to improve cell function and the body’s. Sensitivity to insulin, at least in a laboratory study in mice.

This discovery could lead to new drugs to treat or even prevent diabetes. Previous studies have included filter coffee in these effects, but filter papers trap coffee cup, so cup levels are low (just 0.1 mg).

Instead, a cup of Scandinavian brewed coffee contained 6.2 mg, a cup of Greek coffee 4.2 mg, and coffee grounds filtered with a wire mesh in a glass / container had 2.6 mg.

What the researchers said

Dr. Fredrik Bruster Melby of Aarhus University Hospital said,Coffee contains a large number of bioactive substances. That can be categorized as alkaloids. The main stimulant in coffee, caffeine, has attracted a lot of interest. However, since decaffeinated coffee has the same inverse relationship with the development of type 2 diabetes as caffeinated coffee. It is less likely that all the beneficial effects of coffee.

In a previous study, Dr. Melby and colleagues found that cafestol increased insulin secretion. In pancreatic cells. When they were exposed to glucose. It also increased glucose uptake into muscle cells as effectively as a standard prescription antidiabetic drug.

Diabetes: Objective, method and results of Danish research

In the Danish study, the researchers wanted to see if cafestol could help prevent or delay the onset of type 2 diabetes. In genetically modified mice that became obese after birth the mice prone. Into three groups with two different doses of cafestol (1.1 mg: high dose and 0.4 mg: low dose).

After 10 weeks, fasting plasma glucose was 28-30% lower in both groups of cafestol-treated mice. Compared with the control group, which did not receive the compound. Fasting glucagon was 20% lower and insulin sensitivity improved by 42% in the high-cafestol group. Cafestol also did not lead to hypoglycemia or low blood sugar, a possible side effect of some antidiabetic drugs. Such as insulin and sulfonylureas.

Conclusions

High-dose mice also recorded higher levels of “bad” cholesterol and gained weight. But Dry Melby said: “We expect the oral antidiabetic dose in humans to be relatively low and that the antidiabetic benefits will not be offset by a small increase in LDL cholesterol.”

Note that the mice received the equivalent for humans of 11-31 cups of coffee per day respectively!

He said: “The present study adds further knowledge about the mechanisms of action of bioactive substances in coffee. “Daily consumption of cafestol may delay the onset of type 2 diabetes in these mice and indicate that it is a potential candidate for drug development. To treat or prevent type 2 diabetes in humans.”

Leave a Reply

Your email address will not be published. Required fields are marked *